Fox Chase Cancer Center’s 20 Most Influential Studies

At Fox Chase Cancer Center, groundbreaking research has always been a top priority for propelling cancer care into the future. Since the center’s inception in 1974, scientists and clinicians have been conducting high-impact research that continues to be utilized by the cancer care community. According to Web of Science, a platform that tracks scholarly articles, work by Fox Chase researchers has been cited hundreds of thousands of times over the last 50 years, over 600,000 times over the last 20 years alone. The numbers below are for articles for which a Fox Chase researcher was a high-ranking author. They also demonstrate the degree to which studies by Fox Chase researchers have had an impact on the scientific community, both when the studies were initially published and today.

To learn more about high-impact clinical research from Fox Chase over the years, see “Advancing Cancer Care Through Clinical Trials and Translational Research."

Since the center’s inception in 1974, scientists and clinicians have been conducting high-impact research that continues to be utilized by the cancer care community.

1. Fox Chase Author(s): Hossein Borghaei

Title: Nivolumab Versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

Journal: New England Journal of Medicine

Year Published: 2015

Times Cited: 7,294

2. Fox Chase Author(s): Richard I. Fisher

Title: Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma

Journal: Journal of Clinical Oncology

Year Published: 2014

Times Cited: 3,421

3. Fox Chase Author(s): Margaret von Mehren

Title: Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

Journal: New England Journal of Medicine

Year Published: 2002

Times Cited: 3,342

4. Fox Chase Author(s): Gary Hudes

Title: Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma

Journal: New England Journal of Medicine

Year Published: 2007

Times Cited: 3,127

5. Fox Chase Author(s): Nancy Young

Title: The 2001 Bethesda System - Terminology for Reporting Results of Cervical Cytology

Journal: Journal of the American Medical Association

Year Published: 2002

Times Cited: 2,355

6. Fox Chase Author(s): Elizabeth R. Plimack

Title: Pembrolizumab Plus Axitinib Versus Sunitinib for Advanced Renal-Cell Carcinoma

Journal: New England Journal of Medicine

Year Published: 2019

Times Cited: 2,215

7. Fox Chase Author(s): Gerald Hanks

Title: Defining Biochemical Failure Following Radiotherapy With or Without Hormonal Therapy in Men With Clinically Localized Prostate Cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus Conference

Journal: International Journal of Radiation Oncology Biology Physics

Year Published: 2006

Times Cited: 2,147

8. Fox Chase Author(s): Gayle Bosma, R. Philip Custer, Melvin Bosma

Title: A Severe Combined Immunodeficiency Mutation in the Mouse

Journal: Nature

Year Published: 1983

Times Cited: 2,098

9. Fox Chase Author(s): Igor Astsaturov, Edna Cukierman

Title: A Framework for Advancing Our Understanding of Cancer-Associated Fibroblasts

Journal: Nature Reviews Cancer

Year Published: 2020

Times Cited: 2,009

10. Fox Chase Author(s): Sergei I. Grivennikov

Title: Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Journal: Immunity

Year Published: 2019

Times Cited: 2,007

11. Fox Chase Author(s): Paul J. Catalano, Neal J. Meropol, Peter J. O’Dwyer

Title: Bevacizumab in Combination With Oxaliplatin, Fluorouracil, and Leucovorin (folfox4) for Previously Treated Metastatic Colorectal Cancer: Results From the Eastern Cooperative Oncology Group study e3200

Journal: Journal of Clinical Oncology

Year Published: 2007

Times Cited: 1,883

12. Fox Chase Author(s): Philip N. Tsichlis

Title: The Protein-Kinase Encoded by the AKT Protooncogene is a Target of the PDGF-Activated Phosphatidylinositol 3-Kinase

Journal: Cell

Year Published: 1995

Times Cited: 1,842

13. Fox Chase Author(s): Robert A. Burger

Title: Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer

Journal: New England Journal of Medicine

Year Published: 2011

Times Cited: 1,801

14. Fox Chase Author(s): Alexander Kutikov, Robert Uzzo

Title: The Renal Nephrometry Score: A Comprehensive Standardized System for Quantitating Renal Tumor Size, Location, and Depth

Journal: Journal of Urology

Year Published: 2009

Times Cited: 1,764

15. Fox Chase Author(s): Robert F. Ozols

Title: Phase III Trial of Carboplatin and Paclitaxel Compared With Cisplatin and Paclitaxel in Patients With Optimally Resected Stage III Ovarian Cancer: A Gynecologic Oncology Group Study

Journal: Journal of Clinical Oncology

Year Published: 2003

Times Cited: 1,669

16. Fox Chase Author(s): Kenneth D. Tew

Title: The Importance of Glutathione in Human Disease

Journal: Biomedicine & Pharmacotherapy

Year Published: 2003

Times Cited: 1,558

17. Fox Chase Author(s): Steven J. Cohen, Neal J. Meropol

Title: Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer

Journal: Journal of Clinical Oncology

Year Published: 2008

Times Cited: 1,489

18. Fox Chase Author(s): Richard R. Hardy, Kyoko Hayakawa

Title: Resolution and Characterization of Pro-B and Pre-Pro-B Cell Stages in Normal Mouse Bone-Marrow

Journal: Journal of Experimental Medicine

Year Published: 1991

Times Cited: 1,429

19. Fox Chase Author(s): Neal J. Meropol

Title: Phase II Trial of Cetuximab in Patients With Refractory Colorectal Cancer That Expresses the Epidermal Growth Factor Receptor

Journal: Journal of Clinical Oncology

Year Published: 2004

Times Cited: 1,414

20. Fox Chase Author(s): Edna Cukierman

Title: Modeling Tissue Morphogenesis and Cancer in 3D

Journal: Cell

Year Published: 2007

Times Cited: 1,359